E2-Elimination

The E2 elimination reaction is a one-step reaction in which the leaving group leaves as the same time as the base attacks.

  • Typically 1 and 2 alkyl halides and tosylates undergo E2 elimination in the presence of a strong base.
  • Rate is proportional to the base and alkyl halide concentration.
    • Rate = -k [B-][RX]
    • 2nd order kinetics
    • The following animation illustrates the elimination of H-Cl from chloroethane to yield ethene.


on off Reactants previous next Products

  • The alkyl halide must be able to adopt anti-periplanar geometry.
    • Anti-Periplanar means that the H-C-C-X atoms are in the same plane with a dihedral angle of 180o.
    • The following applet demonstrates Anti-periplanar and Syn-periplanar configurations.

Anti-periplanar Syn-periplanar

    • The stereochemical outcome is controlled by the anti-periplanar geometry.

      E2 Stereochemistry