Enalaprilat, the active form of Enalapril, binds to the active site of Angiotensin-Converting Enzyme (ACE), inhibiting its function. This inhibition prevents the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby lowering blood pressure. The chiral nature of Enalaprilat ensures a precise fit within the ACE binding pocket, highlighting the critical role of stereochemistry in drug design and efficacy.
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