Second Semester Topics

• Arenes and Aromaticity
  • Common Named Arenes
  • Nomenclature
  • Practice Time - Naming Arenes
  • Stability of Aromatics
  • Aromaticity H5P
  • Benzenes MO's
  • Huckel's 4n+2 Rule
  • Frosts Circle
  • Aromatic Ions
  • Aromatic Heterocycles
  • Cyclopentadienyl Anion
• Reactions of Arenes
  • Electrophilic Aromatic Substitution
  • EAS-Halogenation
  • EAS-Nitration
  • Practice Time - Synthesis of Aniline
  • EAS-Alkylation
  • Practice Time - Friedel Crafts Alkylation
  • EAS-Acylation
  • Practice Time - Synthesis of Alkyl Arenes
  • EAS-Sulfonation
  • Practice Time - EAS
  • Effect on Rate and Orientation
  • Donation and Withdrawal of Electrons
  • Regiochemistry in EAS
  • Practice Time - Directing Group Effects
  • Steric Considerations
  • Synthesizing Poly-substituted Benzene's
  • NAS - Addition/Elimination
  • NAS - Elimination/Addition - Benzyne
• Alcohols and Phenols
  • Naming Alcohols
  • Preparation of Alcohols
  • Reactions of Alcohols
  • Structure and Properties
• Ethers and Epoxides
  • Intro and Occurrence
  • Crown Ethers
  • Preparation of Ethers
  • Reactions of Ethers
  • Practice Time - Ethers
  • Preparation of Epoxides
  • Reactions of Epoxides - Acidic Ring Opening
  • Practice Time - Acidic Ring Opening
  • Reactions of Epoxides - Nucleophilic Ring Opening
  • Practice Time - Nucleophilic Ring opening
  • Application - Epoxidation in Reboxetine Synthesis
  • Application - Nucleophilic Epoxide Ring Opening in Crixivan Synthesis
  • Naming Ethers and Epoxides
• Aldehydes and Ketones
  • Naming Aldehydes and Ketones
  • Practice Time - Naming Aldehydes/Ketones
  • Nucleophilic addition
  • Addition of Water - Gem Diols
  • Practice Time - Hydration of Ketones and Aldehydes
  • Addition of Alcohols - Hemiacetals and Acetals
  • Acetal Protecting Groups
  • Hemiacetals in Carbohydrates
  • Practice Time - Hemiacetals and Acetals
  • Addition of Amines - Imines
  • Addition of Amines - Enamines
  • Practice Time - Imines and Enamines
  • Application - Imatinab Enamine Synthesis
  • Addition of CN - Cyanohydrins
  • Practice Time - Cyanohydrins
  • Application - Isentress Synthesis
  • Addition of Ylides - Wittig Reaction
  • Practice Time - Wittig Olefination
• Carboxylic Acids and Derivatives
  • Introduction to Carboxylic Acids
  • Nucleophilic Acyl Substitution
  • Carboxylic Acids
  • Acid Halides
  • Anhydrides
  • Esters
  • Amides
  • Practice Time - Reactions of Carboxylic Acid Derivatives
  • Application: Cardura (Doxazosin) Amidation Step
• Enols and Enolates
  • Introduction to Enols
  • Tautomerization
  • Reactions of Enols
  • Practice Time - Enols and Tautomerism
  • Intro to Enolates
  • Reactions of Enolates
• Condensation Reactions
  • Aldol Reaction
  • Crossed Aldol
  • Aldol Dehydration (Elimination)
  • Claisen Condensation
  • Micheal Addition
  • Robinson Annulation
• Amines