Ionic and Molecular Compounds

Ionic vs. Molecular Compounds

In health science, we distinguish between ionic compounds (electrolytes) and molecular compounds (like sugars and gases) because they behave differently in the human body.

Ionic Compounds (Salts)

  • Bonding: Electrostatic attraction between + and - ions.
  • Composition: Metal + Nonmetal.
  • In Water: Dissociate into electrolytes (conduct electricity).
  • Example: Calcium Carbonate (CaCO3) used in antacids and bone supplements.

Molecular Compounds

  • Bonding: Covalent (sharing electrons).
  • Composition: Two or more nonmetals.
  • In Water: Do not typically conduct electricity.
  • Example: Glucose (C6H12O6), the primary energy source for cells.

An ionic compound has one or more ionic bonds. An ionic bond is a strong electrostatic attraction between a cation and an anion.

For an ion to be created, one or more electrons must leave or enter an atom.

When electrons leave an atom, a (+) cation is created; when electrons enter an atom, a (-) anion is created.

Sodium (Na) has 11 electrons and proton. One of them is able to leave the atom to create a sodium cation (Na+ with only 10 electrons and still has 11 protons and hence the + charge)

Metals form cations; nonmetals form anions.

NaCl is an ionic compound between Na+ and Cl- (1:1 ratio)

CaCl2 is an ionic compound between Ca2+ and 2 Cl- (1:2 ratio)

Al2O3 is an ionic compound between 2 Al3+ and 3 O2- (2:3 ratio)

Both cations and anions are written by their atomic symbol, followed by their positive or negative charge as a superscript.

Metals cations keep the same name:

Ca -> Ca2+ calcium ion

Fe -> Fe2+ or Fe3+ iron ion (though we may say iron (ii) or iron (iii) cation.

Nonmetals change their name by adding a suffix of ‘-ide’

Cl -> Cl- chlorine becomes a chloride ion

O -> O2- oxygen becomes an oxide ion

When a single atom (metal or nonmetal) forms an ion, these are called monoatomic ions.

However, there also exist several types of polyatomic ions, which contain two or more elements that are molecules with an overall positive or negative charge.

Ionic compounds can also have polyatomic ions present.

Calcium carbonate is an ionic compound formed with Ca2+ and the polyatomic carbonate ion (CO32-) to form CaCO3.

Magnesium hydroxide is formed by Mg2+ and 2 hydroxide ions (OH-) as Mg(OH)2 … note here that because the hydroxide is a ‘unit’ and there needs to be two of them to counteract the 2+ on Mg2+, the hydroxide must be placed in parentheses before the subscript.

MgOH2 is incorrect!

Polyatomic Ions

Some ions consist of multiple atoms acting as a single charged unit. These are vital for maintaining blood pH and cellular energy.

Name Formula
Ammonium NH4+
Hydronium H3O+
Hydroxide OH-
Cyanide CN-
carbonate CO32-
bicarbonate HCO3-
nitrate NO3-
nitrite NO2-
sulfate SO42-
phosphate PO43-

NH3 is the molecule ammonia … adding another hydrogen creates the ammonium cation, NH4+

Water (H2O) can create a cation by adding a hydrogen called the hydronium ion (H3O+) or an anion by losing a hydrogen, called the hydroxide ion (OH-)

Practice: Formula Writing

Ions Compound Formula Name
Na+ + OH- NaOH Sodium hydroxide
Mg2+ + 2OH- Mg(OH)2 Magnesium hydroxide
Al3+ + 3OH- Al(OH)3 Aluminum hydroxide
K+ + CO32- K2CO3 Potassium carbonate
Quick Quiz: Which of the following is molecular? (Na2CO3, C6H12O6, KCN) Click for Answer

C6H12O6 (Glucose) is molecular. Na2CO3 and KCN contain metal cations (Sodium and Potassium) paired with polyatomic anions, making them ionic.

 

Let’s practice a few … write out the formulas for the following ionic compounds:

  • Sodium + hydroxide =
  • Aluminum + hydroxide =
  • Calcium + fluoride =
  • Ammonium + hydroxide =
  • Potassium + carbonate =

answers

  • Sodium + hydroxide = NaOH
  • Aluminum + hydroxide = Al(OH)3
  • Calcium + fluoride = CaF2
  • Ammonium + hydroxide = NH4OH
  • Potassium + carbonate = K2CO3

Ionic bonds, again, are strong electrostatic attractions between cations and anions. When cations and anions come together, they do so in a fixed ratio that ensures a neutral compound.

Summary: Ionic vs. Molecular Bonding

Compounds are held together by bonds. Recognizing the difference between ionic and molecular compounds helps predict how a substance will dissolve or react in the bloodstream.

1. Ionic Compounds

Formed by the transfer of electrons, creating an attraction between oppositely charged ions.  Normally ionic compounds are formed from when an alkali/alkaline metal that loses an electron bonds with an atom from the right side of the periodic table that gained an electron. 

  • Cations: Metals that lose electrons (e.g., Sodium ion, Na+).
  • Anions: Nonmetals that gain electrons (e.g., Chloride ion, Cl-).